Introduction to Molecular Biology
This module will provide the learner with an introduction to molecular biology, classification of species and its
applications in medical science. The concept of evolution and sexual reproduction and development will also be
covered, and the processes of inheritance and genetic variation, particularly with regard to evolution and natural
selection. This module will be supported by a practical session and essay with academic support on a topic
relevant to the medical applications of molecular biology.
Skills for Medical Sciences
The aim of this module is to provide the student with basic skills required for laboratory research in the field of
applied medical sciences. The module will be both theoretical and applied: the student will be instructed in methods
essential for data acquisition and analyses but will also actively participate in the laboratory, using broadly
applicable experimental techniques. They will also develop skills that are not experimental techniques themselves,
but are nevertheless fundamental to the scientific process, such as `lab math,¿ sourcing information, referencing,
ethics and health and safety.
Sgiliau ar gyfer Gwyddorau Meddygol
Nod y modiwl hwn yw darparu¿r sgiliau sylfaenol sydd eu hangen ar fyfyrwyr ar gyfer ymchwil labordy ym maes y gwyddorau meddygol cymhwysol. Bydd y modiwl yn cynnwys gwaith damcaniaethol a chymhwysol: caiff y myfyriwr ei hyfforddi mewn dulliau sy¿n hanfodol ar gyfer caffael data a¿i ddadansoddi, ond bydd hefyd yn cymryd rhan weithredol yn y labordy, gan ddefnyddio¿n fras y technegau arbrofol perthnasol. Byddant hefyd yn datblygu sgiliau nad ydynt yn dechnegau arbrofol yn eu hunain, ond sydd er hynny, yn sylfaenol i¿r broses wyddonol, megis, 'mathemateg y labordy¿, cyrchu gwybodaeth, cyfeirnodi, moeseg ac iechyd a diogelwch.
Introduction to Toxicology: The Dose Makes the Poison
We are surrounded by substances that may do our bodies harm i.e. poisons. The harm these poisons causes depends on our exposure - the dose. The science of toxicology, a discipline that crosscuts biology, chemistry, pharmacology, and
medicine, is based on the principle that the dose makes the poison.
This module will provide you with an introduction to toxicology and how dose-response relationships relate to the physiological effects of toxic substances. You will explore how they produce cellular and chemical changes that cause tissues and organs to malfunction.
You will learn how the structure and function of these tissues can be affected to varying degrees and begin to understand how tissue may repair itself and when the damage is reversible, permanent or fatal.
You will also learn how we use toxic substances to our advantage in both the laboratory and within the clinic.
Human physiology is the study of how our body works in an integrated way. A central principle of human physiology is homeostasis, the maintenance of a relatively stable internal environment. Failure to maintain homeostasis disrupts normal function that may lead to disease (or pathophysiology). Students will be taught the key concepts of homeostasis in the physiological systems of the body, enabling the student to understand the consequences of pathophysiology to human health.
Emphasis will be given to how malfunction of key physiological systems gives rise to disease, using specific examples to enable students to appreciate the relationship between physiology/anatomy and medicine. Fundamental principles of physiology will be illustrated with appropriate clinical examples and during lectures and in practical assignments.
Students will gain practical experience in assessing physiological function during four laboratory-based exercises. The impact of pathophysiology of such systems will be assessed through clinical case studies.
Human and Medical Genetics
The course is designed to introduce fundamental concepts in the study of human genetics with particular reference to the application of the principles to medicine. The course covers the role of genetics in human health and disease and methods for the detection of genetic variability in human populations.
Doctors, patients & the goals of medicine
The educational intention of the module is to allow the student to consider the contemporary practice of Medicine within the United Kingdom. This will include understanding the professional regulation, financial constraints and societal and personal challenges, within which medicine and other healthcare activities are practiced.
Meddygon, Cleifion a Nodau Meddygaeth
Bwriad addysgol y modiwl yw caniatáu i'r myfyriwr ystyried arfer cyfoes Meddygaeth yn y Deyrnas Unedig. Bydd hyn yn cynnwys deall y rheoleiddiad proffesiynol, cyfyngiadau ariannol a'r heriau cymdeithasol a phersonol, y mae meddygaeth a gweithgareddau gofal iechyd eraill yn cael eu hymarfer ynddynt.
Contemporary themes and techniques in medical sciences
This module aims to give students an overview of current and emerging themes in medical sciences, both from clinical and laboratory perspectives. This will cover topics generating high media interest, such as the COVID virus and alternative methods of transplantation as well as new laboratory techniques. In addition, the module will be supported by two practical classes for which students will be required to conduct mini-projects based around the identification of patient samples and how these are presented as research cases.
Themau a thechnegau cyfoes yn y gwyddorau meddygol
Nod y modiwl hwn yw rhoi trosolwg i fyfyrwyr o'r themâu presennol a'r rhai sy'n datblygu yn y gwyddorau meddygol, o safbwynt clinigol a'r labordy. Bydd yn ymdrin â phynciau sy'n denu sylw sylweddol yn y cyfryngau, megis y firws Zika a dulliau trawsblannu amgen yn ogystal â thechnegau labordy newydd. Yn ogystal, ategir y modiwl gan ddau ddosbarth ymarferol - disgwylir i fyfyrwyr ymgymryd â phrosiectau bach ar sail dadansoddi samplau cleifion, a sut caiff y rhain eu cyflwyno fel astudiaethau ymchwil. Bydd y modiwl hefyd yn cynnwys 'cynhadledd' undydd pan fydd myfyrwyr yn cyflwyno data ac yn cael profiad o awyrgylch cynhadledd ymchwil.
Pharmacogenomics: Genes on Drugs
Pharmacogenomics is the study of how a person¿s genomic information can affect their response to drugs and therapeutics, predicting if a patient will respond badly, too much or too little to a chosen therapy. This is the underlying principle of `personalised medicine¿, ensuring the right patient, gets the right drug, at the right time.
Within this module, students will look at the principles of pharmacogenomics, namely the variation in genomics sequences from patients to patients which can alter the pharmacokinetics and pharmacodynamics of therapeutics. In this module, students will learn about the role of pharmacogenomics in chemotherapy, gastrointestinal drugs, cardiovascular drugs, respiratory drugs, neurological drugs and drugs used in the treatment of infectious disease.
Population Health & The Art of Research 1
This module introduces students to the philosophical underpinnings, and practical applications of population health research. It has been designed to enable students to develop a real-world understanding of a range of epidemiological and qualitative research methodologies used to investigate population health problems, and an appreciation of the importance of ethics when conducting population health research in practice.
The course is designed to provide an advanced study of the identification of human genes and the determination of the influence of human genes upon disease and health status. Gene identification provides targets for the development of new pharmaceuticals and the range of variation present in the population.
Genetics of Cancer
This module will provide students with an advanced understanding about the genetic mechanisms involved in carcinogenesis, and how these underlying processes and molecules affect the human body.
Advances in Pharmacology
Pharmacology is the science of how drugs act on the body and how the body acts on drugs.
Pharmacology investigates the chemical and physical properties of drugs, how those properties confer actions on living tissues and how those actions affect health and disease. In this module, students will build upon their previous pharmacology knowledge and look more in depth at how the body interacts with drugs (pharmacokinetics) and how the drug interacts with the body (pharmacodynamics).
In this module, students will study the drugs and therapeutics currently used in clinical practise and the underlying mechanisms of action of these drugs. Students will learn about the beneficial, therapeutic effects of drugs, but also some negative consequences of drug administration, such as toxicity, addiction and microbial drug-resistance. Additionally, students will learn about the cutting-edge therapies currently in development for treating disease.
The aim of this module is to provide a capstone experience to students¿ learning, through participating in their own enquiry-based research project. The project may be laboratory or non-laboratory based, but it will always involve a research question that is drawn from the literature, and focused on a topic relevant to the life sciences. It will ask a novel research question and involve the critical analysis of research findings. Students will refine their oral and written communication skills to a graduate level through creating an introductory presentation on the project background, and a written dissertation and oral presentation on their research conclusions.
Reproductive Biology and Medicine
This module is designed to provide students with knowledge of the biochemistry, physiology and pathology of human pregnancy, fetal development, parturition and menopause. Particular focus will be given to fertility treatments and pharmacological interventions of menopause. Lectures will cover a recap of endocrinology of reproduction, and provide details of assisted reproductive technologies. Lectures will be supported by case studies which include current clinical approaches used to treat infertility and menopause.
Cancer remains a significant cause of mortality in the modern world. Current and emerging chemotherapies, and the rationale, experimental, and clinical evidence of the pathways or molecules targeted will be explored. Causes of treatment-related side effects, and the therapies used to address these, will be discussed along with the mechanisms that lead to anti-cancer drug resistance.
This module is for students with an interest in teaching, science communication and Medicine, and involves projects based in local schools/colleges, community groups , science outreach programmes (e.g. Oriel Science) or within Higher Education. The student will engage both in observation and in various teaching activities. The module will be assessed through various methods including a written report and the supervisor¿s report.
This module will encompass a range of communication modes, from presentation of science to the general public to critically analysing a scientific paper.
The module will be run as a series of online seminars to prepare, firstly, for
a short 3 minute thesis-like presentations to both a professional and non-professional audience.
This will be complemented by preparation of short, New Scientist-style articles by each student on the topic of their presentation. Students will be assigned a topic that is appropriate to their degree title.
In the latter half of the module, the focus will be on skills-training for writing a scientific paper, preparing the ground for their project dissertations.
The module is for students to build on their previous knowledge, skills and experience by undertaking a laboratory based or suitable non-laboratory based project on a specific subject related to genomics.
Pharmacogenomics & Stratified Healthcare
Pharmacogenomics and stratified health care ensure that healthcare professionals offer the right treatment, for the right person, at the right time is a fast-developing area.
`Personalised medicine¿ is the buzzword of the moment, with advances in pharmacogenomic testing enabling more effective, targeted therapies to patients in the field of asthma, analgesia, oncology and beyond. Continued understanding of the genomic basis of drug response will reduce drug-related adverse effects, save costs, and ensure a better therapeutic outcome.
This module will provide a comprehensive overview of the analytical strategies and techniques used in pharmacogenomics and explore some of the challenges and limitations in this field. The module will also provide an overview of the different type of pharmacogenomic biomarkers currently in use or emerging and the current feasibility of delivering `personalised medicine¿ in the clinic.